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Target
Son of sevenless homolog 1 [564-1049]
Ligand
BDBM525147
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
IC50
4.77±n/a nM
Citation
 Gill, AL; Buckl, A; Koltun, ES; Aay, N; Tambo-ong, AA; Thompson, S; Gliedt, MJ; Knox, JE; Cregg, J; Edwards, AV; Liu, Y; Burnett, GL Bicyclic heteroaryl compounds and uses thereof US Patent  US11168102 Publication Date 11/9/2021 
Target
Name:
Son of sevenless homolog 1 [564-1049]
Synonyms:
SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56970.22
Organism:
n/a
Description:
aa 564-1049
Residue:
486
Sequence:
EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT
 
Inhibitor
Name:
BDBM525147
Synonyms:
US11168102, Example 32-32.
Type:
Small organic molecule
Emp. Form.:
C26H30F3N5O3
Mol. Mass.:
517.5433
SMILES:
COC1(CCN(CC1)C(C)=O)c1cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nc(C)nc2n(C)c1=O |r|
Structure:
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