Reaction Details Report a problem with these data
Target
Luciferin 4-monooxygenase
Ligand
BDBM526330
Substrate
n/a
Meas. Tech.
YAP Reporter Assay
IC50
<100±n/a nM
Citation
 Konradi, AW; Lin, TT Non-fused tricyclic compounds US Patent  US11186554 Publication Date 11/30/2021 
Target
Name:
Luciferin 4-monooxygenase
Synonyms:
LUCI_LUCMI | Luciferase
Type:
Protein
Mol. Mass.:
60495.67
Organism:
Southern Russian firefly
Description:
Q26304
Residue:
548
Sequence:
MEMEKEENVVYGPLPFYPIEEGSAGIQLHKYMHQYAKLGAIAFSNALTGVDISYQEYFDITCRLAEAMKNFGMKPEEHIALCSENCEEFFIPVLAGLYIGVAVAPTNEIYTLRELNHSLGIAQPTIVFSSRKGLPKVLEVQKTVTCIKKIVILDSKVNFGGHDCMETFIKKHVELGFQPSSFVPIDVKNRKQHVALLMNSSGSTGLPKGVRITHEGAVTRFSHAKDPIYGNQVSPGTAILTVVPFHHGFGMFTTLGYFACGYRVVMLTKFDEELFLRTLQDYKCTSVILVPTLFAILNKSELIDKFDLSNLTEIASGGAPLAKEVGEAVARRFNLPGVRQGYGLTETTSAFIITPEGDDKPGASGKVVPLFKVKVIDLDTKKTLGVNRRGEICVKGPSLMLGYSNNPEATRETIDEEGWLHTGDIGYYDEDEHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPNIFDAGVAGVPDPDAGELPGAVVVMEKGKTMTEKEIVDYVNSQVVNHKRLRGGVRFVDEVPKGLTGKIDAKVIREILKKPQAKM
  
Inhibitor
Name:
BDBM526330
Synonyms:
US11186554, Compound 60 | ethyl 2-(4-(2-((4- (trifluoromethyl)phenyl)amino)phenyl)-1H- pyrazol-1-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C20H18F3N3O2
Mol. Mass.:
389.371
SMILES:
CCOC(=O)Cn1cc(cn1)-c1ccccc1Nc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: