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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Ligand
BDBM527736
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
10.00±n/a nM
Citation
 McGowan, MA; Katz, JD; Zhou, H; Witter, DJ; Li, C; Lipford, KA; Methot, JL; Achab, AA; Fradera, X; Xu, S; Fu, J Purine inhibitors of human phosphatidylinositol 3-kinase delta US Patent  US11179389 Publication Date 11/23/2021 
Target
Name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Synonyms:
PIK3CD | PK3CD_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)(14-604)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67504.18
Organism:
Homo sapiens (Human)
Description:
aa 14-604
Residue:
591
Sequence:
KEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLT
  
Inhibitor
Name:
BDBM527736
Synonyms:
5-{1-(cyclopropylmethyl)-3- [2-(dimethylamino)ethyl]-2- oxo-1,3,8-triazaspiro[4.5]dec- 8-yl}-3-(1-methyl-1H- pyrazol-4-yl)pyrazine-3- carbonitrile | US11179389, Compound 1-4
Type:
Small organic molecule
Emp. Form.:
C24H33N9O
Mol. Mass.:
463.5785
SMILES:
CN(C)CCN1CC2(CCN(CC2)c2cnc(C#N)c(n2)-c2cnn(C)c2)N(CC2CC2)C1=O
Structure:
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