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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Ligand
BDBM527769
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
37.0±n/a nM
Citation
 McGowan, MA; Katz, JD; Zhou, H; Witter, DJ; Li, C; Lipford, KA; Methot, JL; Achab, AA; Fradera, X; Xu, S; Fu, J Purine inhibitors of human phosphatidylinositol 3-kinase delta US Patent  US11179389 Publication Date 11/23/2021 
Target
Name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Synonyms:
PIK3CD | PK3CD_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)(14-604)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67504.18
Organism:
Homo sapiens (Human)
Description:
aa 14-604
Residue:
591
Sequence:
KEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLT
  
Inhibitor
Name:
BDBM527769
Synonyms:
3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- trifluoroethyl)-1,8- diazaspiro[4.5]dec-8- yl]pyrazine-2-carbonitrile | US11179389, Compound 1-21
Type:
Small organic molecule
Emp. Form.:
C19H20F3N7O
Mol. Mass.:
419.4036
SMILES:
Cn1cc(cn1)-c1nc(cnc1C#N)N1CCC2(CCC(=O)N2CC(F)(F)F)CC1
Structure:
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