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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Ligand
BDBM527781
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
300±n/a nM
Citation
 McGowan, MA; Katz, JD; Zhou, H; Witter, DJ; Li, C; Lipford, KA; Methot, JL; Achab, AA; Fradera, X; Xu, S; Fu, J Purine inhibitors of human phosphatidylinositol 3-kinase delta US Patent  US11179389 Publication Date 11/23/2021 
Target
Name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Synonyms:
PIK3CD | PK3CD_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)(14-604)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67504.18
Organism:
Homo sapiens (Human)
Description:
aa 14-604
Residue:
591
Sequence:
KEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLT
  
Inhibitor
Name:
BDBM527781
Synonyms:
5-[(3R)-3-methyl-4-(2-oxa-6- azaspiro[3.3]hept-6- ylcarbonyl)piperazin-1-yl]-3- (1-methyl-1H-pyrazol-4- yl)pyrazine-2-carbonitrile | US11179389, Compound 1-33
Type:
Small organic molecule
Emp. Form.:
C20H24N8O2
Mol. Mass.:
408.457
SMILES:
C[C@@H]1CN(CCN1C(=O)N1CC2(COC2)C1)c1cnc(C#N)c(n1)-c1cnn(C)c1 |r|
Structure:
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