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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Ligand
BDBM527786
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
210±n/a nM
Citation
 McGowan, MA; Katz, JD; Zhou, H; Witter, DJ; Li, C; Lipford, KA; Methot, JL; Achab, AA; Fradera, X; Xu, S; Fu, J Purine inhibitors of human phosphatidylinositol 3-kinase delta US Patent  US11179389 Publication Date 11/23/2021 
Target
Name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604]
Synonyms:
PIK3CD | PK3CD_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)(14-604)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67504.18
Organism:
Homo sapiens (Human)
Description:
aa 14-604
Residue:
591
Sequence:
KEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLT
  
Inhibitor
Name:
BDBM527786
Synonyms:
US11179389, Compound 1-38 | methyl (2R)-4-[5-cyano-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2-yl]-2- methylpiperazine-1- carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H19N7O2
Mol. Mass.:
341.3678
SMILES:
COC(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 |r|
Structure:
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