Reaction Details Report a problem with these data
Target
Triple specificity protein phosphatase PtpB
Ligand
BDBM50544450
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1500±200 nM
Citation
 Zhang, Z; Ruddraraju, KV N-aryl oxamic acids US Patent  US11192850 Publication Date 12/7/2021 
Target
Name:
Triple specificity protein phosphatase PtpB
Synonyms:
PTPB_MYCTU | Phosphoinositide phosphatase | Protein-serine/threonine phosphatase | Protein-tyrosine phosphatase B | TSP PTP | mptpB | ptpB
Type:
Protein
Mol. Mass.:
30152.45
Organism:
n/a
Description:
I6WXK4
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
 
Inhibitor
Name:
BDBM50544450
Synonyms:
CHEMBL4633719 | US11192850, Compound 3
Type:
Small organic molecule
Emp. Form.:
C16H18N2O5
Mol. Mass.:
318.3245
SMILES:
CC(C)(C)OC(=O)NCC#Cc1ccc(NC(=O)C(O)=O)cc1
Structure:
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