Reaction Details Report a problem with these data
Target
Triple specificity protein phosphatase PtpB
Ligand
BDBM50544425
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
57.0±12 nM
Citation
 Zhang, Z; Ruddraraju, KV N-aryl oxamic acids US Patent  US11192850 Publication Date 12/7/2021 
Target
Name:
Triple specificity protein phosphatase PtpB
Synonyms:
PTPB_MYCTU | Phosphoinositide phosphatase | Protein-serine/threonine phosphatase | Protein-tyrosine phosphatase B | TSP PTP | mptpB | ptpB
Type:
Protein
Mol. Mass.:
30152.45
Organism:
n/a
Description:
I6WXK4
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
 
Inhibitor
Name:
BDBM50544425
Synonyms:
CHEMBL4640123 | US11192850, Entry 4e
Type:
Small organic molecule
Emp. Form.:
C20H18N2O6
Mol. Mass.:
382.3667
SMILES:
COC(=O)c1cc(C#Cc2cccc(NC(=O)C(O)=O)c2)c(cc1O)N(C)C
Structure:
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