Reaction Details Report a problem with these data
Target
Triple specificity protein phosphatase PtpB
Ligand
BDBM50544431
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
15.0±3 nM
Citation
 Zhang, Z; Ruddraraju, KV N-aryl oxamic acids US Patent  US11192850 Publication Date 12/7/2021 
Target
Name:
Triple specificity protein phosphatase PtpB
Synonyms:
PTPB_MYCTU | Phosphoinositide phosphatase | Protein-serine/threonine phosphatase | Protein-tyrosine phosphatase B | TSP PTP | mptpB | ptpB
Type:
Protein
Mol. Mass.:
30152.45
Organism:
n/a
Description:
I6WXK4
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
 
Inhibitor
Name:
BDBM50544431
Synonyms:
CHEMBL4637459 | US11192850, Entry 4k
Type:
Small organic molecule
Emp. Form.:
C17H10F3NO3
Mol. Mass.:
333.2614
SMILES:
OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: