Reaction Details Report a problem with these data
Target
Triple specificity protein phosphatase PtpB
Ligand
BDBM50544432
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
88.0±7 nM
Citation
 Zhang, Z; Ruddraraju, KV N-aryl oxamic acids US Patent  US11192850 Publication Date 12/7/2021 
Target
Name:
Triple specificity protein phosphatase PtpB
Synonyms:
PTPB_MYCTU | Phosphoinositide phosphatase | Protein-serine/threonine phosphatase | Protein-tyrosine phosphatase B | TSP PTP | mptpB | ptpB
Type:
Protein
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
I6WXK4
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50544432
Synonyms:
CHEMBL4642274 | US11192850, Entry 4l
Type:
Small organic molecule
Emp. Form.:
C16H12N2O5S
Mol. Mass.:
344.342
SMILES:
NS(=O)(=O)c1ccc(cc1)C#Cc1ccc(NC(=O)C(O)=O)cc1
Structure:
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