Reaction Details Report a problem with these data
Target
Dynein light chain 2, cytoplasmic
Ligand
BDBM528570
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
3300±200 nM
Citation
 Kapoor, TM; Asano, M; Aso, K; Foley, MA; Fukase, Y; Furukawa, H; Hirata, Y; Takashima, S; Okawa, T; Tanaka, Y; Yoshitomi, Y Pyrazoloquinazolinone antitumor agents US Patent  US11192893 Publication Date 12/7/2021 
Target
Name:
Dynein light chain 2, cytoplasmic
Synonyms:
8 kDa dynein light chain b | DLC2 | DLC8b | DYL2_HUMAN | DYNLL2 | Dynein light chain LC8-type 2
Type:
Protein
Mol. Mass.:
10351.24
Organism:
Human
Description:
Q96FJ2
Residue:
89
Sequence:
MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
  
Inhibitor
Name:
BDBM528570
Synonyms:
US11192893, Example 4
Type:
Small organic molecule
Emp. Form.:
C21H12ClF3N4O
Mol. Mass.:
428.794
SMILES:
FC(F)(F)c1ccc2c(c1)c(=O)[nH]c1c(C#N)c(nn21)C1(CC1)c1ccc(Cl)cc1
Structure:
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