Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530543
Substrate
n/a
EC50
22±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530543
Synonyms:
WO2022076764, Example 72
Type:
Small organic molecule
Emp. Form.:
C22H19F4N3O5
Mol. Mass.:
481.397
SMILES:
CCOC(=O)Cc1cn(c(NC(=O)c2ccc(OC(F)F)cc2)n1)-c1c(F)cc(OC)cc1F |(-7.66,1.94,;-6.41,1.04,;-5,1.66,;-3.76,.76,;-3.92,-.77,;-2.35,1.39,;-1.1,.48,;-1.1,-1.06,;.36,-1.53,;1.26,-.29,;2.8,-.29,;3.57,1.04,;2.8,2.38,;5.12,1.04,;5.88,-.29,;7.42,-.29,;8.2,1.04,;9.74,1.04,;10.51,2.38,;9.74,3.71,;12.05,2.38,;7.42,2.38,;5.88,2.38,;.36,.96,;.84,-3,;-.2,-4.14,;-1.7,-3.82,;.28,-5.61,;1.79,-5.93,;2.26,-7.39,;1.23,-8.54,;2.82,-4.79,;2.34,-3.32,;3.37,-2.18,)|
Structure:
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