Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530569
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
6.70±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530569
Synonyms:
WO2022076495, EXAMPLE 15
Type:
Small organic molecule
Emp. Form.:
C24H27F3N4O5S
Mol. Mass.:
540.555
SMILES:
CC(C)n1c2cc(ccc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1 |(-2.25,-.19,;-.74,.13,;.29,-1.01,;-.27,1.6,;1.2,2.07,;2.53,1.3,;3.86,2.07,;3.86,3.61,;2.53,4.38,;1.2,3.61,;-.27,4.09,;-.74,5.55,;.29,6.7,;-.19,8.16,;.84,9.31,;2.35,8.99,;3.38,10.13,;2.9,11.6,;4.88,9.81,;-1.7,8.48,;-2.73,7.34,;-2.25,5.87,;-3.28,4.73,;-1.17,2.84,;-2.71,2.84,;5.2,1.3,;5.2,-.24,;6.53,2.07,;7.87,1.3,;6.88,.12,;8.39,2.75,;9.91,3.02,;10.9,1.84,;11.89,3.02,;12.23,1.07,;10.37,.39,;8.86,.12,)|
Structure:
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