Reaction Details Report a problem with these data
Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM530955
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.120±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM530955
Synonyms:
4-[4-(2- fluoroethyl)piperidin-1-yl]- N1-[(3R)-pyrrolidin-3-yl]-3- (1H-tetrazol-5-yl)benzene- 1,2-disulfonamide | US11207312, Example 87
Type:
Small organic molecule
Emp. Form.:
C18H27FN8O4S2
Mol. Mass.:
502.587
SMILES:
NS(=O)(=O)c1c(ccc(N2CCC(CCF)CC2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 |r|
Structure:
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