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Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM531008
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.100±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM531008
Synonyms:
N1-((R)-3-amino-2- hydroxypropyl)-4-(4-(2- aminoethyl)azepan-1-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide bis(2,2,2- trifluoroacetate) | US11207312, Example 140
Type:
Small organic molecule
Emp. Form.:
C18H31N9O5S2
Mol. Mass.:
517.626
SMILES:
NCCC1CCCN(CC1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN |r|
Structure:
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