Reaction Details Report a problem with these data
Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM531057
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.060±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM531057
Synonyms:
(S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(4- (aminomethyl)piperidin-1-yl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide | US11207312, Example 189
Type:
Small organic molecule
Emp. Form.:
C16H27N9O5S2
Mol. Mass.:
489.573
SMILES:
NC[C@@H](CO)NS(=O)(=O)c1ccc(N2CCC(CN)CC2)c(-c2nn[nH]n2)c1S(N)(=O)=O |r|
Structure:
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