Reaction Details Report a problem with these data
Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM531077
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.120±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM531077
Synonyms:
(R)-N1-(3-amino-2-hydroxypropyl)-4-(4-(2-aminoethoxy)piperidin-1-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide | US11207312, Example 209
Type:
Small organic molecule
Emp. Form.:
C17H29N9O6S2
Mol. Mass.:
519.599
SMILES:
NCCOC1CCN(CC1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN |r|
Structure:
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