Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM532349
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
0.700±n/a nM
Citation
 Rishton, GM; Look, GC; Catalano, SM Compositions for treating neurodegenerative diseases US Patent  US11214540 Publication Date 1/4/2022 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM532349
Synonyms:
US11214540, Example 7
Type:
Small organic molecule
Emp. Form.:
C19H28F3NO
Mol. Mass.:
343.4269
SMILES:
CC(CC(C)(C)c1ccc(cc1)C(F)(F)F)N1CCC(CO)CC1
Structure:
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