Reaction Details
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Sigma non-opioid intracellular receptor 1
Ligand
BDBM532351
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
13.0±n/a nM
Citation
Rishton, GM; Look, GC; Catalano, SM Compositions for treating neurodegenerative diseases US Patent US11214540 Publication Date 1/4/2022 More Info.:
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
Inhibitor
Name:
BDBM532351
Synonyms:
US11214540, Example 9
Type:
Small organic molecule
Emp. Form.:
C26H38F3NO
Mol. Mass.:
437.5812
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6](-[#6]C([#6])([#6])c1ccc(cc1)C(F)(F)F)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6]-1)-[#6]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1
Structure:
