Reaction Details
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Report a problem with these dataTarget
Sigma intracellular receptor 2
Ligand
BDBM532357
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
4.50±n/a nM
Citation
Rishton, GM; Look, GC; Catalano, SM Compositions for treating neurodegenerative diseases US Patent US11214540 Publication Date 1/4/2022 More Info.:
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
Inhibitor
Name:
BDBM532357
Synonyms:
US11214540, Example 15
Type:
Small organic molecule
Emp. Form.:
C25H38FNO
Mol. Mass.:
387.5737
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6](-[#6]C([#6])([#6])c1ccc(F)cc1)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6]-1)-[#6]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1
Structure:
