Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM532363
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
8.00±n/a nM
Citation
 Rishton, GM; Look, GC; Catalano, SM Compositions for treating neurodegenerative diseases US Patent  US11214540 Publication Date 1/4/2022 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM532363
Synonyms:
US11214540, Example 21 | US11214540, Example 65
Type:
Small organic molecule
Emp. Form.:
C23H34FNO
Mol. Mass.:
359.5206
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6](-[#6]-[#6]-c1ccc(F)cc1)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6]-1)-[#6]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1
Structure:
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