Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349576
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay 2
Ki
11.0±n/a nM
Citation
 Rishton, GM; Look, GC; Catalano, SM Compositions for treating neurodegenerative diseases US Patent  US11214540 Publication Date 1/4/2022 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM349576
Synonyms:
US10207991, Ex. Cpd. No. 101 | US10611728, Example Compound 101 | US11214540, Example 26 | US11691947, Example 101
Type:
Small organic molecule
Emp. Form.:
C22H29NO4S
Mol. Mass.:
403.535
SMILES:
COc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1OC
Structure:
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