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Target
Mixed lineage kinase domain-like protein
Ligand
BDBM534547
Substrate
n/a
Meas. Tech.
MLKL Phosphorylation High-Content Assay
IC50
0.50±n/a nM
Citation
 Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Mixed lineage kinase domain-like protein
Synonyms:
MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL
Type:
PROTEIN
Mol. Mass.:
54493.57
Organism:
Homo sapiens
Description:
ChEMBL_104428
Residue:
471
Sequence:
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
  
Inhibitor
Name:
BDBM534547
Synonyms:
3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(2,2-difluoro-3-hydroxy-3-(2,4,6-trifluorophenyl)propyl)-2-fluoro-6-methylbenzamide | WO2022086828, Example 283
Type:
Small organic molecule
Emp. Form.:
C23H17F6N5O2
Mol. Mass.:
509.4038
SMILES:
Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC(F)(F)[C@@H](O)c1c(F)cc(F)cc1F |r|
Structure:
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