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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM534281
Substrate
n/a
Meas. Tech.
RIPK1 HTRF Binding Assay
IC50
6.20±n/a nM
Citation
 Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM534281
Synonyms:
WO2018148626, Example 9 | WO2022086828, Example 9
Type:
Small organic molecule
Emp. Form.:
C23H21F2N5O2
Mol. Mass.:
437.4419
SMILES:
Cc1cc(F)c(cc1C(=O)NCC[C@@H](O)c1ccc(F)cc1)-c1ccn2nc(N)nc2c1 |r|
Structure:
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