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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM536183
Substrate
n/a
Meas. Tech.
VHL HEK-293 BRET Assay
IC50
5480±n/a nM
Citation
 Blaquiere, N; Dragovich, P; Gazzard, LJ; Pillow, T; Staben, ST; Wei, B; Xin, J (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof US Patent  US11242344 Publication Date 2/8/2022 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM536183
Synonyms:
2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-4-oxo-4,5-dihydro-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)isoindolin-1-one | US11242344, Example 123.1 | US11242344, Example 123.2
Type:
Small organic molecule
Emp. Form.:
C31H33N5O4S
Mol. Mass.:
571.69
SMILES:
CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C |r,t:25|
Structure:
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