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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM536215
Substrate
n/a
Meas. Tech.
VHL HEK-293 BRET Assay
IC50
24500±n/a nM
Citation
 Blaquiere, N; Dragovich, P; Gazzard, LJ; Pillow, T; Staben, ST; Wei, B; Xin, J (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof US Patent  US11242344 Publication Date 2/8/2022 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM536215
Synonyms:
(2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one | US11242344, Example 128.3 | US11242344, Example 128.4
Type:
Small organic molecule
Emp. Form.:
C22H28N4O4
Mol. Mass.:
412.4821
SMILES:
CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccccc1)c1cc(C)no1 |r,t:13|
Structure:
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