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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM536264
Substrate
n/a
Meas. Tech.
VHL HEK-293 BRET Assay
IC50
25700±n/a nM
Citation
 Blaquiere, N; Dragovich, P; Gazzard, LJ; Pillow, T; Staben, ST; Wei, B; Xin, J (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof US Patent  US11242344 Publication Date 2/8/2022 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM536264
Synonyms:
1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl) butan-1-one (2 Single Stereoisomers) | US11242344, Example 115.1 | US11242344, Example 115.2
Type:
Small organic molecule
Emp. Form.:
C19H31N5O3
Mol. Mass.:
377.4811
SMILES:
CCN1N=C(NC1(C)C)[C@@H]1C[C@@H](O)CN1C(=O)C(C(C)C)c1cc(C)no1 |r,c:3|
Structure:
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