Reaction Details
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Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Ligand
BDBM50383380
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
2.30±n/a nM
Citation
Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US11247972 Publication Date 2/15/2022 More Info.:
Target
Name:
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Synonyms:
cGMP-dependent protein kinase (CpCDPK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80612.61
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
Q5CTY5
Residue:
718
Sequence:
MMGQGQNALNGVCSRRYEKDSIEINKNKEVRRKQSNKRGNFPAHNMTHGKPEYLKEAVDRLINHGNIVGNSPDRYLAKERKSQASCSTSDPTSPLAYRNGNDNYFEQYEICDLIELTSEMALSNESRFESLSEYESIPKLSPSTTVMGITDVSATNTSNSNSATPTESEKGSGPKLSLTEGKFRREGLIPACKGSIHSDYIIDSGRIGKGTYGSVKSGTNRLTGCIRAIKTIPLTRVEALDNFMKEINILKNLDHPNIVKLYETYQDKENIYLVMELCSGGELFDRIISQGSFDEIYAANLMKQVLSTICYCHDHGIVHRDLKPENFLFLNKNYNAPLKIIDFGLAARVNNEDTSLNTRAGTPYYVAPEVLQGKYDKQCDMWSLGVILYILLCGYPPFHGSNDSIILHKVQKGVYAFKEEDWKHVSFLAIDLIRKLLTYNPSERITARDALNHPWITRFADDILFLSPRNYFYSNDGFMKTGIVSSDYIDSSINNLKALECQQKPRNCNLMGSRRNGYIKGGLRYCRSKRRSISSSSGLNLLSNFRAFHKYNRFMKVALTVIAQQMTESQISNLKEAFILLDANCDGTLTPQEIITGLKNSGITELPSDLLAILNDIDSDGSGSIDYTEFIAATLDSKQYSKEQVCWAAFKVFDQDGNGKITANELLNVFSYNSEQGSAGINDKALSDVKNMIKEVDVDGDGEIDFQEFLEMFRRSNS
Inhibitor
Name:
BDBM50383380
Synonyms:
CHEMBL2030553 | CHEMBL2070047 | US10544104, Compound 28 | US11247972, Compound 28 | US9765037, Compound 28
Type:
Small organic molecule
Emp. Form.:
C22H24N6O
Mol. Mass.:
388.4656
SMILES:
COc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Structure:
