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Target
cGMP-dependent protein kinase
Ligand
BDBM340946
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
4.90±n/a nM
Citation
 Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US11247972 Publication Date 2/15/2022 
Target
Name:
cGMP-dependent protein kinase
Synonyms:
KGP_TOXGO | PKG | TgPKG
Type:
Protein
Mol. Mass.:
111249.85
Organism:
n/a
Description:
Q8MMZ7
Residue:
994
Sequence:
MGACISKNSSARVSRSSALSASKQTVAASAPPGAAGDETSATGAAEEASRNSLARVDGTRASAAELERAPDGVCPDREEPGTANAEQGGVTEKKDTRETLAGMNSPKTLEAEAQEDDPKREAPNQDVPSEAPEGPKEKPGGDRKPAQKAILKQDDSHTEEEKLNAHLAYREKTPADFALIQDSLKANLVCSSLNEGEIDALAVAMQFFTFKKGDVVTKQGEPGSYFFIIHSGTFDVLVNDKRVNAMDKGKAFGEIALIHNTERSATVVASSTEGALWGVQRHTFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVENFKPGQPIVKEGDAGDVLYILKSGKAKVSIGGREIRMLRKGDYFGERALLYKEPRSATITAEEFTVCVSIGRELLDRVLGNLQHVLFRNIMVEALQQSKVYELFQGDQLSKLIEAAVVKDYGADYVILDKENKTKGIRFFFVLEGELSVYAYTQNPATKEEERKLAATLKRGQAFGEEYVLNPTRPFNHYVKSVGPCKLALFTSSVLTATLGGEDIDETLDFNNKRAIIRKMYIFRYLSDHQMTMLIKAFKTVRYMSGEYIIKEGERGTRFFIIKAGEVAILKNNKRLRTLGRHDYFGERALLYDKPRTASVCANSAGVDLWVVDKSVFNEIIKGPMLAHLEERIRMQDTKVEFQDLQVVRVVGRGTFGTVKLVRHVPTDIRYALKCVSRRSVIALSQQQHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLARSQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILTGKLVFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFGDFDWDKLAGRGLPPPLAPKGETYAEDTEQSSFELDEDDTIVLEDEYDWDKDF
 
Inhibitor
Name:
BDBM340946
Synonyms:
3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[1,5-a]pyrazin-8-amine | US10544104, Compound 71 | US11247972, Compound 71 | US9765037, Compound 71
Type:
Small organic molecule
Emp. Form.:
C21H22N4O
Mol. Mass.:
346.4256
SMILES:
COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: