Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM541764
Substrate
n/a
Meas. Tech.
Inhibitory Activities Assay
IC50
>200±n/a nM
Citation
 Wang, H Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof US Patent  US11267815 Publication Date 3/8/2022 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM541764
Synonyms:
US11267815, Example 17
Type:
Small organic molecule
Emp. Form.:
C24H17Cl2N5O6S
Mol. Mass.:
574.393
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n2cc(nc12)-c1ccc(cc1)[N+]([O-])=O)S(C)(=O)=O |(2.8,1.84,;4.13,1.07,;4.13,-.47,;5.47,-1.24,;5.47,-2.78,;6.8,-3.55,;8.13,-2.78,;4.13,-3.55,;4.13,-5.09,;2.8,-2.78,;2.8,-1.24,;1.47,-.47,;1.47,-3.55,;.13,-2.78,;-1.2,-3.55,;-2.53,-2.78,;-3.87,-3.55,;-3.87,-5.09,;-2.53,-5.86,;-1.2,-5.09,;.13,-5.86,;.45,-7.37,;1.98,-7.53,;2.61,-6.12,;1.47,-5.09,;2.75,-8.86,;1.98,-10.2,;2.75,-11.53,;4.37,-11.59,;5.06,-10.2,;4.29,-8.86,;5.16,-12.91,;4.41,-14.26,;6.7,-12.89,;-5.2,-5.86,;-6.54,-5.09,;-5.2,-7.4,;-5.2,-4.32,)|
Structure:
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