Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM543095
Substrate
n/a
Meas. Tech.
FGFR4 Activity Inhibition Test
IC50
24.6±n/a nM
Citation
 Shao, N; Wang, D; Yuan, H; Kayser, F Aromatic derivative, preparation method for same, and medical applications thereof US Patent  US11279697 Publication Date 3/22/2022 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM543095
Synonyms:
US11279697, Compound 140
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N5O3
Mol. Mass.:
476.356
SMILES:
COc1cc(OC)c(Cl)c(C2CCc3c(C2)[nH]nc3-c2c(NC(=O)C=C)cnn2C)c1Cl |(-4,7.12,;-2.67,7.89,;-1.33,7.12,;,7.89,;1.33,7.12,;2.67,7.89,;4,7.12,;1.33,5.58,;2.67,4.81,;,4.81,;,3.27,;-1.33,2.5,;-1.33,.96,;,.19,;1.33,.96,;1.33,2.5,;2.48,-.07,;1.85,-1.48,;.32,-1.32,;-.45,-2.65,;.03,-4.12,;1.51,-4.51,;1.91,-6,;.82,-7.09,;3.4,-6.4,;3.8,-7.89,;-1.22,-5.02,;-2.47,-4.12,;-1.99,-2.65,;-2.76,-1.32,;-1.33,5.58,;-2.67,4.81,)|
Structure:
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