Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM543102
Substrate
n/a
Meas. Tech.
FGFR4 Activity Inhibition Test
IC50
2.96±n/a nM
Citation
 Shao, N; Wang, D; Yuan, H; Kayser, F Aromatic derivative, preparation method for same, and medical applications thereof US Patent  US11279697 Publication Date 3/22/2022 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM543102
Synonyms:
US11279697, Compound 281-P2
Type:
Small organic molecule
Emp. Form.:
C22H23F2N5O3
Mol. Mass.:
443.4465
SMILES:
COc1cc(OC)c(F)c([C@H]2CCc3c(C2)[nH]nc3-c2c(NC(=O)C=C)cnn2C)c1F |r,wD:10.9,(-8.87,.68,;-7.39,1.07,;-6.3,-.01,;-6.7,-1.5,;-5.61,-2.59,;-6.01,-4.08,;-7.49,-4.48,;-4.12,-2.19,;-3.03,-3.28,;-3.72,-.7,;-2.23,-.31,;-1.33,-1.55,;.2,-1.39,;.83,.02,;-.08,1.26,;-1.61,1.1,;.83,2.51,;2.29,2.03,;2.29,.49,;3.63,-.28,;4.87,.63,;4.87,2.17,;6.21,2.94,;6.21,4.48,;7.54,2.17,;8.87,2.94,;6.12,-.28,;5.64,-1.74,;4.1,-1.74,;3.33,-3.08,;-4.81,.38,;-4.41,1.87,)|
Structure:
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