Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM543449
Substrate
n/a
Meas. Tech.
FGFR4 Activity Inhibition Test
IC50
203±n/a nM
Citation
 Shao, N; Wang, D; Yuan, H; Kayser, F Aromatic derivative, preparation method for same, and medical applications thereof US Patent  US11279697 Publication Date 3/22/2022 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM543449
Synonyms:
US11279697, Compound 311-P1
Type:
Small organic molecule
Emp. Form.:
C22H24ClN5O3
Mol. Mass.:
441.911
SMILES:
COc1cc(OC)c(Cl)c(c1)[C@@H]1CCc2c(C1)[nH]nc2-c1c(NC(=O)C=C)cnn1C |r,wU:11.11,(-2.74,-6.44,;-4.07,-5.67,;-4.07,-4.13,;-5.4,-3.36,;-5.4,-1.82,;-6.74,-1.05,;-8.07,-1.82,;-4.07,-1.05,;-4.07,.49,;-2.74,-1.82,;-2.74,-3.36,;-1.4,-1.05,;-.07,-1.82,;1.27,-1.05,;1.27,.49,;-.07,1.26,;-1.4,.49,;.25,2.77,;1.78,2.93,;2.41,1.52,;3.9,1.13,;4.8,2.37,;4.4,3.86,;5.49,4.95,;5.09,6.44,;6.98,4.55,;8.07,5.64,;6.27,1.9,;6.27,.36,;4.8,-.12,;4.03,-1.45,)|
Structure:
Search PDB for entries with ligand similarity: