Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM543516
Substrate
n/a
Meas. Tech.
AlphaLisa Assay
IC50
13.0±n/a nM
Citation
 Upadhayaya, RS; Kethiri, R; Madan, S; Rajaiah, SK Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof US Patent  US11279703 Publication Date 3/22/2022 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM543516
Synonyms:
US11279703, TABLE 6.119 | US11279703, TABLE 6.128 | US11279703, TABLE 6.149 | US11279703, TABLE 6.154 | US11279703, TABLE 6.168 | US11279703, TABLE 6.181 | US11279703, TABLE 6.194 | US11279703, TABLE 6.199 | US11279703, TABLE 6.204 | US11279703, TABLE 6.215 | US11279703, TABLE 6.244 | US11279703, TABLE 6.262 | US11279703, TABLE 6.276 | US11279703, TABLE 6.298 | US11279703, TABLE 6.307 | US11279703, TABLE 6.314 | US11279703, TABLE 6.319 | US11279703, TABLE 6.328 | US11279703, TABLE 6.37 | US11643396, Example MA2-014
Type:
Small organic molecule
Emp. Form.:
C26H35N7O2S
Mol. Mass.:
509.667
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(NS(=O)(=O)C(C)(C)C)c3)n2)cc1
Structure:
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