Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 3 [51-123]
Ligand
BDBM543479
Substrate
n/a
Meas. Tech.
AlphaLisa Assay
IC50
49.0±n/a nM
Citation
 Upadhayaya, RS; Kethiri, R; Madan, S; Rajaiah, SK Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof US Patent  US11279703 Publication Date 3/22/2022 
Target
Name:
Bromodomain-containing protein 3 [51-123]
Synonyms:
BRD3 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)(BD1) | Bromodomain-containing protein 3 Bromo 1 domain(BRD3 BD1) | KIAA0043 | RING3L
Type:
n/a
Mol. Mass.:
8887.10
Organism:
Homo sapiens (Human)
Description:
BD1 (51-123 aa) of Q15059
Residue:
73
Sequence:
WKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIV
  
Inhibitor
Name:
BDBM543479
Synonyms:
US11279703, TABLE 6.289 | US11279703, TABLE 6.296 | US11279703, TABLE 6.320 | US11279703, TABLE 6.331 | US11279703, Table 1.2
Type:
Small organic molecule
Emp. Form.:
C29H35F2N7O2S
Mol. Mass.:
583.696
SMILES:
CN(C)C1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4ccc(F)c(NS(=O)(=O)C(C)(C)C)c4)c3n2)cc1F
Structure:
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