Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 3 [51-123]
Ligand
BDBM543795
Substrate
n/a
Meas. Tech.
AlphaLisa Assay
IC50
158±n/a nM
Citation
 Upadhayaya, RS; Kethiri, R; Madan, S; Rajaiah, SK Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof US Patent  US11279703 Publication Date 3/22/2022 
Target
Name:
Bromodomain-containing protein 3 [51-123]
Synonyms:
BRD3 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)(BD1) | Bromodomain-containing protein 3 Bromo 1 domain(BRD3 BD1) | KIAA0043 | RING3L
Type:
n/a
Mol. Mass.:
8887.10
Organism:
Homo sapiens (Human)
Description:
BD1 (51-123 aa) of Q15059
Residue:
73
Sequence:
WKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIV
  
Inhibitor
Name:
BDBM543795
Synonyms:
US11279703, TABLE 6.385 | US11279703, TABLE 6.386
Type:
Small organic molecule
Emp. Form.:
C27H30FN7O3S
Mol. Mass.:
551.636
SMILES:
CC(C)(C)S(=O)(=O)Nc1cccc(c1)-n1ccc2cnc(Nc3ccc(C(=O)N4CCNCC4)c(F)c3)nc12
Structure:
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