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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM546413
Substrate
n/a
Meas. Tech.
Compound Primary Screening
EC50
>10000±n/a nM
Citation
 Castro, AC; McComas, CC; Vacca, J RAD51 inhibitors US Patent  US11291655 Publication Date 4/5/2022 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM546413
Synonyms:
US11291655, No E19
Type:
Small organic molecule
Emp. Form.:
C23H25N7O2S3
Mol. Mass.:
527.685
SMILES:
CC(C)NC(=S)Nc1ccc(cc1)-c1ncc(s1)-c1ccc(Nc2nccn2C)cc1S(N)(=O)=O
Structure:
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