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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM546416
Substrate
n/a
Meas. Tech.
Compound Primary Screening
EC50
<5000±n/a nM
Citation
 Castro, AC; McComas, CC; Vacca, J RAD51 inhibitors US Patent  US11291655 Publication Date 4/5/2022 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM546416
Synonyms:
US11291655, No E21
Type:
Small organic molecule
Emp. Form.:
C29H40N6O5S4
Mol. Mass.:
680.925
SMILES:
CC(C)NC(=S)Nc1ccc(-c2cnc(s2)-c2ccc(NC(C)=O)cc2S(=O)(=O)NC(C)(C)C)c(c1)S(=O)(=O)NC(C)(C)C
Structure:
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