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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Ligand
BDBM547777
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<10±n/a nM
Citation
 Andrews, M; Greve, DR; Larsen, J Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors US Patent  US11292799 Publication Date 4/5/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Protein
Mol. Mass.:
23661.98
Organism:
Homo sapiens (Human)
Description:
Q08499[538-740]
Residue:
203
Sequence:
VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
  
Inhibitor
Name:
BDBM547777
Synonyms:
Methyl (3R)-3-(((5R)-2-(3-(4-Fluorophenoxy)azetidin-1-yl)-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate | US11292799, Example 7
Type:
Small organic molecule
Emp. Form.:
C22H26FN5O4S
Mol. Mass.:
475.536
SMILES:
COC(=O)N1CCC[C@H](C1)Nc1nc(nc2CC[S@@+]([O-])c12)N1CC(C1)Oc1ccc(F)cc1 |r|
Structure:
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