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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Ligand
BDBM547783
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<10±n/a nM
Citation
 Andrews, M; Greve, DR; Larsen, J Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors US Patent  US11292799 Publication Date 4/5/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Protein
Mol. Mass.:
23661.98
Organism:
Homo sapiens (Human)
Description:
Q08499[538-740]
Residue:
203
Sequence:
VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
  
Inhibitor
Name:
BDBM547783
Synonyms:
(R)-4-(Bicyclo[1.1.1]pentan-1-ylamino)-2-(3-(3-fluorophenyl)azetidin-1-yl)-6,7-dihydrothieno[3,2-d]pyrimidine 5-oxide | US11292799, Example 13
Type:
Small organic molecule
Emp. Form.:
C20H21FN4OS
Mol. Mass.:
384.47
SMILES:
[O-][S@@+]1CCc2nc(nc(NC34CC(C3)C4)c12)N1CC(C1)c1cccc(F)c1 |r|
Structure:
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