Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Ligand
BDBM547785
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<10±n/a nM
Citation
 Andrews, M; Greve, DR; Larsen, J Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors US Patent  US11292799 Publication Date 4/5/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [538-740]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN
Type:
Protein
Mol. Mass.:
23661.98
Organism:
Homo sapiens (Human)
Description:
Q08499[538-740]
Residue:
203
Sequence:
VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
  
Inhibitor
Name:
BDBM547785
Synonyms:
(R)-4-((1-Methylcyclobutyl)amino)-2-(3-(pyridin-2-yl)azetidin-1-yl)-6,7-dihydrothieno[3,2-d]pyrimidine 5-oxide | US11292799, Example 15
Type:
Small organic molecule
Emp. Form.:
C19H23N5OS
Mol. Mass.:
369.484
SMILES:
CC1(CCC1)Nc1nc(nc2CC[S@@+]([O-])c12)N1CC(C1)c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity: