Reaction Details Report a problem with these data
Target
Interleukin-17 receptor A/
Ligand
BDBM548234
Substrate
n/a
Meas. Tech.
Human IL-17A x IL-17RA TR-FRET assay
IC50
29±n/a nM
Citation
 Josef, TT; David, O; Pascal, F; Klaus, W; Achim, S INTERLEUKIN-17 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Interleukin-17 receptor A/
Synonyms:
Human IL-17A/IL-17RA | Interleukin-17A/Interleukin-17 receptor A
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Component 2
Name:
Interleukin-17 receptor A
Synonyms:
CDw217 | I17RA_HUMAN | IL-17 receptor A | IL-17RA | IL17R | IL17RA
Type:
Protein
Mol. Mass.:
96092.10
Organism:
Human
Description:
Q96F46
Residue:
866
Sequence:
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA
  
Inhibitor
Name:
BDBM548234
Synonyms:
WO2022091056, Example 225
Type:
Small organic molecule
Emp. Form.:
C25H25ClFN5O3
Mol. Mass.:
497.949
SMILES:
Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)[C@@H]2C[C@@H]3C[C@@H]3C2)cc1F |wU:16.17,26.28,28.30,30.31,(-8.89,-2.11,;-9.37,-3.57,;-8.34,-4.72,;-8.82,-6.18,;-7.79,-7.33,;-10.32,-6.5,;-11.35,-5.36,;-10.88,-3.89,;-11.91,-2.75,;-6.83,-4.4,;-5.8,-5.54,;-4.3,-5.22,;-3.82,-3.76,;-2.31,-3.44,;-1.84,-1.97,;-2.87,-.83,;-.33,-1.65,;.14,-.19,;1.65,.13,;2.68,-1.01,;2.13,1.6,;1.22,2.84,;2.13,4.09,;3.59,3.61,;3.59,2.07,;4.84,1.17,;.7,-2.8,;.38,-4.3,;1.71,-5.07,;3.22,-5.39,;2.86,-4.04,;2.23,-2.64,;-4.85,-2.61,;-6.36,-2.93,;-7.39,-1.79,)|
Structure:
Search PDB for entries with ligand similarity: