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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-741]
Ligand
BDBM549179
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<10±n/a nM
Citation
 Larsen, J; Nielsen, SF; Andersen, P Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors US Patent  US11299497 Publication Date 4/12/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-741]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (S380-L740) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-740]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41417.35
Organism:
Homo sapiens (Human)
Description:
aa 380-740
Residue:
361
Sequence:
SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
  
Inhibitor
Name:
BDBM549179
Synonyms:
(5R)?N2-ethyl-5-oxido-N4-tetrahydropyran-4-yl-N2-(2-tetrahydropyran-4-ylethyl)-6,7-dihydrothieno[3,2-d]pyrimidin-5-ium-2,4-diamine | US11299497, Example 2
Type:
Small organic molecule
Emp. Form.:
C20H32N4O3S
Mol. Mass.:
408.558
SMILES:
CCN(CCC1CCOCC1)c1nc2CC[S@@+]([O-])c2c(NC2CCOCC2)n1 |r|
Structure:
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