Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-741]
Ligand
BDBM549301
Substrate
n/a
Meas. Tech.
PDE4 Assay
IC50
<10±n/a nM
Citation
Larsen, J; Nielsen, SF; Andersen, P Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors US Patent US11299497 Publication Date 4/12/2022
More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-741]
Synonyms:
DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (S380-L740) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-740]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41417.35
Organism:
Homo sapiens (Human)
Description:
aa 380-740
Residue:
361
Sequence:
SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
Inhibitor
Name:
BDBM549301
Synonyms:
2-chloro-N-[(1R)-1- methylpropyl]-5- oxido-6,7-dihydro- thieno[3,2-d]pyrimi- din-5-ium-4-amine | US11299497, Example 16
Type:
Small organic molecule
Emp. Form.:
C21H28N4O3S
Mol. Mass.:
416.537
SMILES:
COc1cccc(Nc2nc(nc3CC[S@@+]([O-])c23)N(C)CCC2CCOCC2)c1 |r|