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Target
Atypical chemokine receptor 3
Ligand
BDBM549890
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
6.00±n/a nM
Citation
 Aissaoui, H; Guerry, P; Lehembre, F; Pothier, J; Pouzol, L; Richard-Bildstein, S; Yuan, S Piperidine CXCR7 receptor modulators US Patent  US11306078 Publication Date 4/19/2022 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM549890
Synonyms:
(3S,4S)-4-{[5-(2,4-Difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-1- (2,2-dimethyl-propyl)-piperidine-3-carboxylic acid (1-pyrimidin-2-yl- cyclopropyl)-amide | US11306078, Example 2.069
Type:
Small organic molecule
Emp. Form.:
C28H32F2N6O3
Mol. Mass.:
538.5889
SMILES:
CC(C)(C)CN1CC[C@H](NC(=O)c2cc(on2)-c2ccc(F)cc2F)[C@H](C1)C(=O)NC1(CC1)c1ncccn1
Structure:
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