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Target
Atypical chemokine receptor 3
Ligand
BDBM550067
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1.000±n/a nM
Citation
 Aissaoui, H; Guerry, P; Lehembre, F; Pothier, J; Pouzol, L; Richard-Bildstein, S; Yuan, S Piperidine CXCR7 receptor modulators US Patent  US11306078 Publication Date 4/19/2022 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM550067
Synonyms:
(3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3- carbonyl]-amino}-piperidine-3-carboxylic acid (1-methyl-1-pyrimidin-2-yl- ethyl)-amide | US11306078, Example 4.102
Type:
Small organic molecule
Emp. Form.:
C27H30F2N6O3
Mol. Mass.:
524.5623
SMILES:
CC(C)(NC(=O)[C@H]1CN(CC2CC2)CC[C@@H]1NC(=O)c1cc(on1)-c1ccc(F)cc1F)c1ncccn1
Structure:
Search PDB for entries with ligand similarity: