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Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Ligand
BDBM50506477
Substrate
n/a
Meas. Tech.
Cell Based Assays
IC50
>10000±n/a nM
Citation
 Kelly, PF; Ashwell, S; Thomson, B; Collis, A; Davis, J; Walker, D; Lu, W Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) US Patent  US11311527 Publication Date 4/26/2022 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Synonyms:
IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46607.23
Organism:
Homo sapiens (Human)
Description:
O75874[R132C]
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM50506477
Synonyms:
CHEMBL4456162 | US11311527, Cpd ID I-5 | US11376246, Cpd ID I-5 | US11576906, Compound I-5
Type:
Small organic molecule
Emp. Form.:
C18H16ClN3O2
Mol. Mass.:
341.792
SMILES:
Clc1ccc2[nH]c(=O)c(CNc3cccn(C4CC4)c3=O)cc2c1
Structure:
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