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Target
Lethal factor
Ligand
BDBM8509
Substrate
Peptide Substrate
Meas. Tech.
Fluorescence Resonance Energy Transfer Assay (FRET)
IC50
37±n/a nM
Citation
Xiong, Y; Wiltsie, J; Woods, A; Guo, J; Pivnichny, JV; Tang, W; Bansal, A; Cummings, RT; Cunningham, BR; Friedlander, AM; Douglas, CM; Salowe, SP; Zaller, DM; Scolnick, EM; Schmatz, DM; Bartizal, K; Hermes, JD; MacCoss, M; Chapman, KT The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett 16:964-8 (2006) [PubMed] Article
More Info.:
Target
Name:
Lethal factor
Synonyms:
Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor
Type:
PROTEIN
Mol. Mass.:
93758.56
Organism:
Bacillus anthracis
Description:
ChEMBL_1460338
Residue:
809
Sequence:
MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
Inhibitor
Name:
BDBM8509
Synonyms:
(2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-4-(formamidomethanaminium)-N-hydroxybutanamide | hydroxamate analogue 46
Type:
Small organic molecule
Emp. Form.:
C13H20FN4O5S
Mol. Mass.:
363.385
SMILES:
Cc1cc(ccc1F)S(=O)(=O)N[C@H](CCNC(=O)C[NH3+])C(=O)NO |r|
Substrate
Name:
Peptide Substrate
Synonyms:
(Cou)Consensus(K(QSY-35)GG)-NH2
Type:
Peptide
Mol. Mass.:
9139.37
Organism:
n/a
Description:
n/a
Residue:
78
Sequence:
HYDRYMETHYLACETYLCMARINYLNLEKKKKVLPIQLNAATDKNNITRENADIALYLAMINPHENYLACETYLGGNH