Reaction Details
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Hsp90 chaperone protein kinase-targeting subunit
Ligand
BDBM551740
Substrate
n/a
Meas. Tech.
FP-based equilibrium competition assay
EC50
1330±n/a nM
Citation
Brown, LE; Huang, DS; Cowen, LE; Whitesell, L; Marcyk, P Hsp90 inhibitors and uses thereof US Patent US11312722 Publication Date 4/26/2022 More Info.:
Target
Name:
Hsp90 chaperone protein kinase-targeting subunit
Synonyms:
F5H9H0_CRYNB
Type:
Protein
Mol. Mass.:
57233.28
Organism:
Filobasidiella neoformans
Description:
F5H9H0
Residue:
505
Sequence:
MPLNYSKWDMLELSDDSDIEEHPNVDKKSMIRWKQRDIHEKREARKLLISKLKSELSLNSVLRPRIETIISGLSSSGLDHYRAVQRRMKEDPSPEKPETGAPNQPTYDMMLSQLLSDVFREGAWLVEGGRIEGNGVLYNGKKVDDNTGLPDWATAEVPEGKKELLAEKLEQRLRWHVSELNRRDEQVKKEIEKEEGELKKKITSDDIHEGWSSSKIAPPKPSVWDETPRPKKDKKTEKVETIEVLNPKASSSAAPVAPATEDTDDEEDFGPLSPAGRAFAQIPLGDFEKAYDFIKNDSSVLSSSTHDSLLAEAFDAERRGDKSLAMRCVHQSLLVNYCRQLGKDGVGLFFQKMIQKNPKSITMFNEDFQRTYNRIATRTREILAEEAAAGPSGEREQIQLVATDPNMTIAFNLPDGPPPEKILLEGEGVEELDMEQVRAWLQRKWEIFKSFPPRFQEALQTENLDKVNQALGDMKVSEAEKIVELLQEGGMLSFSEKGVRDMTNQ
Inhibitor
Name:
BDBM551740
Synonyms:
US11312722, Compound 30
Type:
Small organic molecule
Emp. Form.:
C24H28N4O4
Mol. Mass.:
436.5035
SMILES:
COc1ccc(Cn2nc(C)cc2Nc2cc(O)cc(O)c2C(=O)N(C)CC2CC2)cc1
Structure:
