Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM552063
Substrate
n/a
Meas. Tech.
BRD4 Biochemical Activity Test
IC50
11.0±n/a nM
Citation
 Shen, C; Wu, C; Liu, Y; Gong, Z; Li, J; Chen, S Thienodiazepine derivatives and application thereof US Patent  US11312726 Publication Date 4/26/2022 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM552063
Synonyms:
US11312726, Compound 34
Type:
Small organic molecule
Emp. Form.:
C29H26ClN5O2S
Mol. Mass.:
544.067
SMILES:
Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3[C@H]4CC[C@H](O4)c3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8|
Structure:
Search PDB for entries with ligand similarity: